Description

L-Threonine-13C is a stable isotope-labeled analog of the essential amino acid L-Threonine, where the carbon-13 isotope is incorporated into its molecular structure. This compound is a critical tool for advanced research and analytical applications, enabling precise metabolic pathway tracing and quantitative analysis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and nutritional science sectors for applications such as mass spectrometry, NMR spectroscopy, and clinical diagnostics.

Application

• Metabolic Research & Tracer Studies: Used as a stable isotope tracer to investigate amino acid metabolism, protein synthesis, and biochemical pathways in vivo and in vitro.
• Quantitative Mass Spectrometry (MS): Serves as an internal standard for the accurate quantification of L-Threonine in complex biological matrices like plasma, urine, and tissue samples.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Employed in structural biology and metabolic profiling studies due to its distinct NMR signature.
• Pharmaceutical Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug compounds and their metabolites.
• Clinical Diagnostics: Applied in the development of assays for detecting inborn errors of metabolism related to threonine catabolism.
• Nutritional Science Research: Facilitates studies on protein utilization, amino acid requirements, and the metabolic effects of dietary supplements.

Basic Information

Product Name	L-Threonine-13C
CAS No.	81202-08-6
Molecular Formula	C413CH9NO3
Molecular Weight	120.10 g/mol (approx.)
Synonyms	(2S,3R)-2-Amino-3-hydroxy-13C-butyric acid; L-(-)-Threonine-13C; (2S,3R)-2-Azaniumyl-3-hydroxy-13C-butanoate; Threonine-13C; Stable Isotope Labeled L-Threonine; 13C-L-Threonine
EINECS	Contact for details

Quality Control

Our L-Threonine-13C is manufactured under strict quality control protocols to ensure high isotopic and chemical purity, essential for sensitive research applications. Each batch is analyzed using advanced techniques including NMR and LC-MS to confirm isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (atom % 13C), chemical purity, and specific analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Isotopic Purity (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Optical Rotation	[α]D20: -28.0° to -30.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.