Description

L-Glutamic Acid (1-13C) is a stable isotope-labeled analog of the essential amino acid L-glutamic acid, where the carbon at the 1-position is the carbon-13 isotope. This product is critical for advanced research and analytical applications requiring precise metabolic tracing and quantification. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications such as metabolic pathway analysis, NMR spectroscopy, and mass spectrometry-based proteomics.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism and amino acid biosynthesis pathways in cells and microorganisms.
• NMR Spectroscopy: Serves as an internal standard or labeled substrate for structural elucidation and dynamic studies of biomolecules.
• Mass Spectrometry (MS): Employed in quantitative proteomics and metabolomics for accurate peptide and metabolite quantification using stable isotope dilution.
• Drug Metabolism & Pharmacokinetics (DMPK): Acts as a labeled precursor in the synthesis of isotopically labeled drug candidates for absorption, distribution, metabolism, and excretion (ADME) studies.
• Biochemical Research: A key reagent for enzymatic assays and studies of glutamate-related neurological functions and signaling.
• Diagnostic Agent Development: Potential use in the formulation of advanced diagnostic probes and imaging agents for medical research.

Basic Information

Product Name	L-Glutamic Acid (1-13C)
CAS No.	81201-99-2
Molecular Formula	C413CH9NO4
Molecular Weight	148.11 g/mol
Synonyms	(1-13C)-L-Glutamic Acid; L-Glutamic-1-13C Acid; (S)-2-Aminopentanedioic-1-13C Acid; 13C Labeled L-Glutamic Acid; Glutamic Acid-1-13C; (S)-(+)-Glutamic Acid-1-13C; 1-13C-L-Glu; [1-13C]Glutamic Acid
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid (1-13C) is manufactured under strict quality systems to ensure high isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to relevant industry guidelines for stable isotope-labeled compounds to ensure batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Specific Rotation [α]20/D	+31.5° to +32.5° (c=2 in 2N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.