Description

Boronophenylalanine B-10 is a boronated amino acid derivative, specifically the boron-10 enriched isotopologue of Boronophenylalanine (BPA). This compound is a critical component in Boron Neutron Capture Therapy (BNCT), an advanced, targeted radiation treatment for certain cancers. Its primary value lies in its ability to selectively deliver the non-radioactive boron-10 isotope to tumor cells, where it can capture thermal neutrons and induce a highly localized cytotoxic reaction. This makes it an essential material for pharmaceutical research, clinical trial development, and advanced therapeutic manufacturing in the oncology sector.

Application

• Boron Neutron Capture Therapy (BNCT): As the active pharmaceutical ingredient (API) or a key precursor in formulations for treating malignant tumors such as glioblastoma, head and neck cancers, and melanoma.
• Pharmaceutical R&D: Used in the development and optimization of new BNCT drug candidates and delivery systems to enhance tumor targeting and therapeutic efficacy.
• Clinical Research: Supplied for use in preclinical studies and human clinical trials to evaluate the safety and dosage of BNCT protocols.
• Isotope-Labeled Compound Synthesis: Serves as a specialized building block for synthesizing other boron-10 labeled compounds for diagnostic or research purposes.
• Nuclear Medicine: Employed in research related to targeted alpha therapy (TAT) and other emerging radiopharmaceutical fields where boron plays a role.
• Biochemical Research: Used as a tool to study amino acid transport mechanisms in cancer cells due to its structural similarity to phenylalanine.

Basic Information

Product Name	Boronophenylalanine B-10
CAS No.	80994-59-8
Molecular Formula	C9H12B10NO4
Molecular Weight	209.01 g/mol (for 10B isotopologue)
Synonyms	BPA-10B; L-4-Boronophenylalanine-10B; Boronophenylalanine enriched in Boron-10; 4-Borono-L-phenylalanine-10B; BPA (10B); L-BPA-10B; (S)-2-Amino-3-(4-boronophenyl)propionic acid-10B; BNCT Agent BPA-10
EINECS	Contact for details

Quality Control

Our Boronophenylalanine B-10 is manufactured under strict quality systems suitable for research and pharmaceutical applications. Each batch is subjected to rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Key parameters include HPLC assay for chemical purity, isotopic abundance of Boron-10, and specific tests for related substances and residual solvents. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against established specifications. We support compliance with cGMP guidelines for advanced therapeutic ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant in the storage area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment (10B)	≥ 95.0 atom %
Specific Optical Rotation	-20.0° to -25.0° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.