Description

Leucine Thiorphan CAS NO 80970-04-3 is a specialized synthetic peptide derivative, recognized as a potent and selective inhibitor of the enzyme neprilysin (NEP). This compound is of significant value in biochemical and pharmacological research for modulating neuropeptide and peptide hormone signaling pathways. It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in neuroscience, cardiovascular research, and drug discovery programs.

Application

• Biochemical Research Tool: Used as a selective neprilysin (NEP) inhibitor to study the degradation and physiological roles of endogenous peptides like enkephalins, substance P, and atrial natriuretic factor (ANF).
• Neuroscience & Pain Research: Investigated for its potential to enhance endogenous opioid activity by inhibiting enkephalin degradation, relevant to studies on analgesia and neurological disorders.
• Cardiovascular Research: Employed in studies exploring the regulation of blood pressure and natriuresis through the inhibition of atrial natriuretic peptide (ANP) breakdown.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in the production of related pharmaceutical compounds.
• Preclinical Drug Development: Acts as a key intermediate or pharmacophore in the design and synthesis of novel therapeutic agents targeting neprilysin for conditions like heart failure and hypertension.
• Enzyme Kinetics Studies: Utilized in vitro to determine enzyme inhibition constants (Ki, IC50) and elucidate the mechanism of action of neprilysin.

Basic Information

Product Name	Leucine Thiorphan
CAS No.	80970-04-3
Molecular Formula	C₁₅H₂₂N₂O₄S
Molecular Weight	326.41 g/mol
Synonyms	N-[(2R,3R)-3-Mercapto-2-benzyl-1-oxopentyl]-L-leucine; (R,R)-Thiorphan; DL-Thiorphan, Leu-isomer; NSC 326231; L-Leucine, N-[(2R,3R)-3-mercapto-2-benzyl-1-oxopentyl]-; Leucine-thiorphan; N-[1-Oxo-2-benzyl-3-mercaptopentyl]leucine; Neprilysin Inhibitor
EINECS	Contact for details

Quality Control

Our Leucine Thiorphan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.