Description

Concanamycin A is a potent and specific macrolide antibiotic that functions as a highly selective inhibitor of vacuolar-type H+-ATPase (V-ATPase). This compound is a critical research tool for studying intracellular pH regulation, vesicular trafficking, and autophagy processes. It is essential for researchers and developers in the fields of cell biology, pharmacology, and biochemistry, particularly for investigating cancer mechanisms, osteoclast function, and neurodegenerative diseases.

Application

• Biochemical Research: A primary tool for selectively inhibiting V-ATPase activity to study lysosomal acidification, organelle pH, and intracellular membrane transport.
• Cancer Research: Used to investigate the role of V-ATPase in tumor cell metastasis, drug resistance, and the acidic tumor microenvironment.
• Neuroscience Studies: Applied in research on neurotransmitter uptake and storage in synaptic vesicles, which is dependent on the proton gradient established by V-ATPase.
• Bone Biology: Utilized to study osteoclast function and bone resorption, processes driven by V-ATPase-dependent acid secretion.
• Antifungal & Antimicrobial Studies: Serves as a reference compound in the discovery and development of new V-ATPase-targeting therapeutic agents.
• Cell Signaling Pathways: Employed to dissect signaling cascades and cellular processes like autophagy and receptor-mediated endocytosis that require V-ATPase activity.

Basic Information

Product Name	Concanamycin A
CAS No.	80890-47-7
Molecular Formula	C₄₆H₇₅NO₁₄
Molecular Weight	878.1 g/mol
Synonyms	Concanamycin A; Antibiotic X 4357B; Folimycin; NSC 326450; V-ATPase inhibitor I; 14-Deoxy-12,13-didehydro-23-O-methyl-6-deoxy-23-demethoxy-5-O-mycaminosyltylonolide; ConA
EINECS	Contact for details

Quality Control

Our Concanamycin A is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and biological activity assays. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Biological Activity (IC50)	≤ 10 nM (V-ATPase inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.