Description

o-Desmethyl Tramadol HCl is a key pharmaceutical intermediate and metabolite of the analgesic tramadol. This compound is of significant importance for research and development in pharmacology and analytical chemistry, particularly in metabolic pathway studies and bioanalytical method validation. It is primarily needed by pharmaceutical R&D laboratories, analytical service providers, and manufacturers of reference standards for use in clinical studies and quality control processes.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of tramadol-related compounds and novel analgesic formulations.
• Metabolite Reference Standard: Used as a certified reference material (CRM) for the quantification of tramadol's active metabolite (M1) in biological matrices during pharmacokinetic and bioequivalence studies.
• Analytical Chemistry: Serves as a high-purity standard for calibrating HPLC, LC-MS, and GC-MS systems in forensic, clinical, and pharmaceutical quality control laboratories.
• Pharmacological Research: Employed in in vitro and in vivo studies to investigate the mechanism of action, potency, and safety profile of tramadol's active form.
• Diagnostic Development: Utilized in the development and validation of immunoassays and other diagnostic kits designed to detect tramadol and its metabolites.

Basic Information

Product Name	o-Desmethyl Tramadol HCl
CAS No.	80456-81-1
Molecular Formula	C15H23NO2•HCl
Molecular Weight	285.81 g/mol (Free base: 249.35 g/mol)
Synonyms	O-Desmethyltramadol Hydrochloride; Tramadol Metabolite M1 HCl; (+)-O-Desmethyltramadol Hydrochloride; (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Hydrochloride; M1 Metabolite of Tramadol; DS-101; CRM for Tramadol Metabolite
EINECS	Contact for details

Quality Control

Our o-Desmethyl Tramadol HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.