Description

Fredericamycin A CAS NO 80455-68-1 is a complex, polycyclic aromatic antibiotic and antitumor agent of significant research interest. This compound matters for its unique mechanism of action, which involves DNA intercalation and topoisomerase inhibition, making it a valuable tool in oncology and microbiology research. It is primarily needed by pharmaceutical R&D laboratories, academic institutions, and biotechnology companies engaged in anticancer drug discovery and the study of novel antibiotic scaffolds.

Application

• Anticancer Research: Serves as a lead compound and biochemical tool for studying DNA interaction mechanisms and developing novel chemotherapeutic agents.
• Antibiotic Studies: Used in microbiological research to investigate its activity against Gram-positive bacteria and its unique structural class.
• Biochemical Pathway Analysis: Employed as a specific inhibitor to probe topoisomerase function and DNA damage response pathways in cellular models.
• Medicinal Chemistry: Provides a complex molecular scaffold for semi-synthetic modification and structure-activity relationship (SAR) studies.
• Reference Standard: Used as a high-purity analytical standard in quality control and pharmacological testing within research settings.

Basic Information

Product Name	Fredericamycin A
CAS No.	80455-68-1
Molecular Formula	C29H21NO9
Molecular Weight	527.48 g/mol
Synonyms	Fredericamycin A; Antibiotic U-58,431; U-58,431; NSC-305263; 5,12-Dihydroxy-8,16-dimethoxy-7-methyl-6H,16H-5,12-epoxybenzo[5,6]cycloocta[1,2,3-cd:4,5,6-c'd']diindole-6,16-dione; FR-900405; FR 900405
EINECS	Contact for details

Quality Control

Our Fredericamycin A is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and safety data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.