Description

2,3,4,6-Tetrafluorotoluene is a highly fluorinated aromatic compound, a derivative of toluene where four hydrogen atoms are replaced by fluorine. This fluorination imparts unique chemical stability and volatility, making it a valuable intermediate and solvent in advanced chemical synthesis. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors for applications requiring inert, high-performance reaction media or building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key fluorinated synthon in the development of active pharmaceutical ingredients (APIs), particularly for introducing fluorine atoms to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms enhance product activity and environmental persistence.
• Liquid Crystal & Electronic Chemicals: Acts as a precursor or solvent in the manufacture of fluorinated liquid crystals for displays and other electronic materials.
• Specialty Solvent: Employed as a high-volatility, inert solvent for demanding chemical reactions and purification processes where traditional solvents are unsuitable.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions and nucleophilic aromatic substitution to create complex fluorinated organic molecules for research and development.
• Polymer Modification: Can be used to introduce fluorine functionality into polymers, altering their surface properties, chemical resistance, and thermal stability.

Basic Information

Product Name	2,3,4,6-Tetrafluorotoluene
CAS No.	80427-49-2
Molecular Formula	C7H4F4
Molecular Weight	164.10 g/mol
Synonyms	α,α,α,2-Tetrafluorotoluene; 2,3,4,6-Tetrafluoro-1-methylbenzene; Toluene, 2,3,4,6-tetrafluoro-; 1-Methyl-2,3,4,6-tetrafluorobenzene; 2,3,4,6-Tetrafluoromethylbenzene; Tetrafluorotoluene (mixed isomer); F4-Toluene (specific isomer)
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Tetrafluorotoluene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment. We adhere to cGMP principles where required to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Density (20°C)	~1.4 g/mL
Boiling Point	~140-145°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.