Description

Scopolamine Hydrochloride, [n-Methyl-3H] is a tritium-labeled derivative of the well-known tropane alkaloid, scopolamine. This radiolabeled compound is essential for advanced pharmacological and neurochemical research, enabling precise tracking and quantification in biological systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) conducting studies on cholinergic systems, drug metabolism, receptor binding assays, and pharmacokinetics.

Application

• Receptor Binding Assays: Used as a high-specific-activity tracer for muscarinic acetylcholine receptor (mAChR) studies to determine binding affinity (Kd) and receptor density (Bmax).
• Pharmacokinetic & ADME Research: Tracks the absorption, distribution, metabolism, and excretion (ADME) of scopolamine and related compounds in preclinical models.
• Neuropharmacology Studies: Investigates the role of cholinergic pathways in memory, learning, and conditions like motion sickness or Parkinson's disease.
• Autoradiography: Enables precise anatomical localization of mAChR binding sites in tissue sections for neurological research.
• Metabolic Pathway Tracing: Elucidates the metabolic fate and biotransformation pathways of tropane alkaloids.
• Competitive Displacement Experiments: Serves as a reference ligand in screening experiments for novel muscarinic receptor agonists or antagonists.

Basic Information

Product Name	Scopolamine Hydrochloride, [n-Methyl-3H]
CAS No.	80324-61-4
Molecular Formula	C17H21NO4 • HCl (³H labeled)
Molecular Weight	~339.8 g/mol (unlabeled form)
Synonyms	(-)-Scopolamine Hydrochloride [N-Methyl-³H]; [³H]Scopolamine Methyl Chloride; 6β,7β-Epoxy-1αH,5αH-tropan-3α-ol (-)-tropate Hydrochloride [N-Methyl-³H]; Tritiated Scopolamine HCl; L-Hyoscyamine, 6,7-epoxytropine tropate hydrochloride [³H-labeled]; [N-Methyl-³H]Scopolamine Hydrochloride; ³H-Scopolamine HCl
EINECS	Contact for details

Quality Control

Every batch of Scopolamine Hydrochloride, [n-Methyl-3H] is produced and analyzed under strict quality protocols to ensure high radiochemical purity and specific activity, critical for sensitive research applications. Our quality assurance includes rigorous analysis via HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Production follows GLP (Good Laboratory Practice) principles to guarantee batch-to-batch consistency and data integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions are recommended to be stored at -20°C in a dark place. Users must handle all radioactive materials according to their institutional radiation safety guidelines.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, TLC)	Conforms to reference standard
Specific Activity	60-90 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol:Water or as specified
Concentration	1 mCi/mL (Contact for other concentrations)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.