Description

Complement C2-Depleted Serum, Human is a specialized biological reagent prepared from human serum by selectively removing the C2 component of the complement system. This product is critical for researchers and diagnostic developers as it provides a defined, controlled matrix for studying the classical and lectin pathways of complement activation without C2 interference. It is an essential tool for immunology research, autoimmune disease studies, and the development and quality control of complement-based diagnostic assays.

Application

• Immunological Research: Used as a key reagent to dissect the specific roles of the classical and lectin complement pathways in immune responses, inflammation, and disease models.
• Diagnostic Assay Development: Serves as a critical component in the research, validation, and quality control (QC) of diagnostic kits that measure complement activity or detect complement-fixing antibodies.
• Autoimmune Disease Studies: Employed to investigate the pathogenesis of conditions like systemic lupus erythematosus (SLE) and rheumatoid arthritis, where complement activation plays a central role.
• Biopharmaceutical Testing: Used in functional assays to evaluate the impact of therapeutic antibodies, vaccines, and other biologics on the complement system.
• Control Serum for Specific Pathways: Acts as a negative control in complement fixation tests (CFT) and other functional assays to confirm the specificity of pathway activation.
• Teaching and Method Standardization: Provides a standardized reagent for academic teaching and for establishing reproducible laboratory protocols in complementology.

Basic Information

Product Name	Complement C2-Depleted Serum, Human
CAS No.	80295-40-5
Molecular Formula	N/A (Complex biological mixture)
Molecular Weight	N/A (Complex biological mixture)
Synonyms	C2-Deficient Human Serum; Human C2-Depleted Serum; Complement Component 2 Deficient Serum; C2d Human Serum; Classical Pathway Complement-Depleted Serum (C2-); Human Serum, Complement C2-Depleted; Immunological Reagent Serum
EINECS	Contact for details

Quality Control

Our Complement C2-Depleted Serum, Human is manufactured and tested under strict quality systems. Each lot undergoes rigorous functional testing to confirm the absence of C2 hemolytic activity while preserving the integrity of other complement components. Certificates of Analysis (COA) are provided, detailing parameters such as residual C2 activity, total complement activity, and sterility. Production adheres to guidelines suitable for research and in vitro diagnostic (IVD) use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C. Avoid repeated freeze-thaw cycles. Thaw slowly at 2-8°C before use. Handle as a potentially biohazardous material of human origin using appropriate biosafety level (BSL) precautions.

Specification

Item	Specification
Description	Clear to slightly opalescent liquid
Source	Human Serum
Depleted Component	Complement C2
Residual C2 Hemolytic Activity	< 5% of normal human serum
Functional Activity (Alternative Pathway)	Preserved
Sterility (Bacteria/Fungi)	Negative
Mycoplasma	Not detected
Storage	-20°C or below, protected from light

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.