Description

C1 Esterase Inhibitor is a critical plasma-derived protein that regulates the complement system, a key component of the innate immune response. This compound is essential for controlling the classical complement pathway, preventing excessive or inappropriate inflammatory activity. It is primarily utilized in pharmaceutical research, diagnostic development, and the production of therapeutic agents for conditions related to complement system dysregulation, such as hereditary angioedema (HAE).

Application

• Therapeutic Protein Development: Serves as the active pharmaceutical ingredient (API) in treatments for hereditary angioedema (HAE) and other complement-mediated disorders.
• Biomedical Research: Used as a key reagent in immunology and inflammation studies to investigate the classical complement pathway and its role in disease models.
• Diagnostic Manufacturing: Employed in the production of calibration standards and controls for clinical diagnostic assays that measure complement activity or C1 inhibitor levels.
• Reference Standard: Acts as a high-purity standard in quality control laboratories for the analysis of plasma-derived products and biotherapeutics.
• Cell Culture & Biotechnology: Utilized in specialized cell culture media and bioprocessing to modulate complement activity in vitro.

Basic Information

Product Name	C1 Esterase Inhibitor
CAS No.	80295-38-1
Molecular Formula	Contact for details
Molecular Weight	Approx. 105 kDa
Synonyms	C1 Inhibitor; C1-INH; C1 Esterase Inactivator; C1 Inactivator; SERPING1; Plasma Protease C1 Inhibitor; Complement 1 Esterase Inhibitor; Hereditary Angioedema Protein
EINECS	Contact for details

Quality Control

Our C1 Esterase Inhibitor is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting high standards for research and pharmaceutical use. Certificates of Analysis (COA) detailing specifications such as activity (IU/mg), purity by SDS-PAGE, and endotoxin levels are provided to guarantee reliable and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or inert atmosphere conditions to maintain stability. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (IR)	Conforms to reference standard
Assay (Functional Activity)	≥ 90% of labeled activity
Purity (SDS-PAGE)	≥ 95%
Protein Content	By UV absorbance
pH (in solution)	6.5 - 7.5
Endotoxin	< 10 EU/mg
Sterility	Sterile (where applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.