Description

4-(β-Amidinoethenyl)Phenyl-4-Guanidinobenzoate Dimethanesulfonate is a high-purity, non-peptidic small molecule compound featuring a bis-guanidino pharmacophore. This chemical is of significant interest in pharmaceutical research and development, particularly as a potent and selective inhibitor of serine proteases. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics for conditions involving dysregulated proteolytic activity. The compound offers a critical tool for biochemical assay development and structure-activity relationship studies.

Application

• Protease Inhibition Research: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of serine protease inhibitors.
• Biochemical Assays: Used as a potent inhibitor in enzymatic studies to elucidate the function and mechanism of specific trypsin-like proteases.
• Pharmaceutical R&D: Acts as a core scaffold or lead compound for medicinal chemistry programs targeting thrombotic, inflammatory, or oncological pathways.
• Diagnostic Reagent Development: Employed in the formulation of specialized diagnostic kits that require precise control of protease activity.
• Academic Research: Utilized in university and institutional labs for fundamental studies in enzymology and signal transduction.

Basic Information

Product Name	4-(β-Amidinoethenyl)Phenyl-4-Guanidinobenzoate Dimethanesulfonate
CAS No.	80251-33-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-(2-Amidinoethenyl)phenyl 4-guanidinobenzoate dimethanesulfonate; CVS-1123; BOC-D-PHE-PRO-ARG-H DIMETHANESULFONATE; (2S)-5-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]pentanedioic acid
EINECS	Contact for details

Quality Control

Our 4-(β-Amidinoethenyl)Phenyl-4-Guanidinobenzoate Dimethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.