Description

10,10-Difluoro-13-Dehydroprostacyclin is a fluorinated analog of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. This compound is of significant interest in advanced pharmaceutical research for developing novel therapeutic agents targeting cardiovascular and thrombotic disorders. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of next-generation cardiovascular drugs and biochemical probes.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel prostacyclin analogs for cardiovascular therapy.
• Biochemical Research: Used as a potent agonist to study prostacyclin (IP) receptor signaling pathways, platelet function, and vascular smooth muscle relaxation in vitro.
• Preclinical Studies: Employed in animal models to investigate the efficacy and pharmacokinetics of fluorinated prostacyclin derivatives for treating pulmonary hypertension and thrombosis.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in HPLC and LC-MS assays within pharmaceutical manufacturing.

Basic Information

Product Name	10,10-Difluoro-13-Dehydroprostacyclin
CAS No.	80226-91-1
Molecular Formula	C₂₀H₂₈F₂O₅
Molecular Weight	386.44 g/mol
Synonyms	10,10-Difluoro-13,14-didehydroprostacyclin; 10,10-Difluoro-13,14-didehydro-PGI₂; 5,6,7-Trinor-4,8-inter-m-phenylene-3-hydroxy-9,10-difluoro-13,14-didehydro-PGI₂; 10,10-Difluoro-15-deoxy-13,14-didehydroprostacyclin; 10,10-Difluoro-13-dehydro-PGI2; 10,10-Difluoro-13,14-didehydro-PGI2; Fluorinated Prostacyclin Analog; 10,10-Difluoro-13,14-didehydroprostaglandin I2
EINECS	Contact for details

Quality Control

Our 10,10-Difluoro-13-Dehydroprostacyclin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.