Description

5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its pyridine core and trifluoromethyl substituent. This compound matters for its unique combination of aromatic stability, acidity, and the lipophilicity and metabolic stability imparted by the fluorine atoms, making it a critical intermediate in advanced synthesis. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and material science.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized as a core structure for designing molecular probes and tags to study biological processes and enzyme functions.

Basic Information

Product Name	5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid
CAS No.	80194-69-0
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	2-Pyridinecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)picolinic acid; 5-Trifluoromethylpyridine-2-carboxylic acid; 2-Carboxy-5-(trifluoromethyl)pyridine; 5-Trifluoromethyl-2-pyridinecarboxylic acid; Picolinic acid, 5-(trifluoromethyl)-; 80194-69-0
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.