Description

Clofibric Pyranoglucuronate is a key metabolite and reference standard of the lipid-regulating agent clofibrate. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism and pharmacokinetics (DMPK). It serves as a critical analytical standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors requiring precise quantification and identification in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative analysis of clofibrate and its metabolites in drug development studies.
• Metabolite Identification & Profiling: Critical for DMPK studies to understand the metabolic pathways, bioavailability, and excretion profiles of clofibrate.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, and GC-MS methods for pharmacokinetic and toxicokinetic assays.
• Clinical Research: Supports clinical trials by enabling accurate monitoring of drug and metabolite levels in patient plasma, serum, or urine samples.
• Quality Control in Manufacturing: Employed in the QC laboratories of active pharmaceutical ingredient (API) manufacturers to ensure batch consistency and purity.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with FDA, EMA) requiring detailed characterization of drug metabolites.

Basic Information

Item	Detail
Product Name	Clofibric Pyranoglucuronate
CAS No.	80183-07-9
Molecular Formula	C19H24O10
Molecular Weight	412.39 g/mol
Synonyms	Clofibrate Pyranoglucuronate; Clofibric Acid Pyranoglucuronide; 1-O-(4-Chlorophenoxy)-3-methylbutyryl-β-D-glucopyranuronic Acid; CPG; Clofibrate Metabolite Glucuronide; 2-(4-Chlorophenoxy)-2-methylpropanoic acid glucuronide (pyranose form); ATROMID-S Metabolite
EINECS	Contact for details

Quality Control

Our Clofibric Pyranoglucuronate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with relevant guidelines for reference standards. Custom purity grades and specialized packaging are available to meet specific research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. For long-term storage, consider storing desiccated at -20°C. This material is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.