Description

Benzene, 1-(Chloromethyl)-4-Fluoro-2-Methyl- is a versatile fluorinated aromatic building block characterized by its reactive chloromethyl and fluoro substituents. This compound is essential for the synthesis of complex molecules, offering precise control over molecular architecture in advanced chemical processes. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce functional groups into polymer chains, altering physical properties like solubility, thermal stability, and chemical resistance.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures common in medicinal chemistry.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating custom fluorinated compounds for various R&D projects.

Basic Information

Product Name	Benzene, 1-(Chloromethyl)-4-Fluoro-2-Methyl-
CAS No.	80141-92-0
Molecular Formula	C8H8ClF
Molecular Weight	158.60 g/mol
Synonyms	4-Fluoro-2-methylbenzyl chloride; 1-(Chloromethyl)-4-fluoro-2-methylbenzene; 2-Methyl-4-fluorobenzyl chloride; α-Chloro-4-fluoro-2-methyltoluene; (4-Fluoro-2-methylphenyl)methyl chloride; 4-Fluoro-o-tolylmethyl chloride; 4-Fluoro-2-methylbenzylchloride; 2-Methyl-4-fluorobenzylchloride
EINECS	Contact for details

Quality Control

Our Benzene, 1-(Chloromethyl)-4-Fluoro-2-Methyl- is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its light-sensitive nature and reactivity, it is recommended to store under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.