Description

18,18,20-Trimethylprostaglandin E2 is a synthetic analog of prostaglandin E2, a potent bioactive lipid mediator. This modified compound is valued for its enhanced metabolic stability and targeted biological activity compared to its natural counterpart. It serves as a critical research tool and potential intermediate in the development of novel therapeutic agents, primarily targeting the pharmaceutical and life science research sectors.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of drugs targeting inflammation, pain, and reproductive health.
• Biochemical Research: Used in in vitro and in vivo studies to investigate prostaglandin receptor (EP receptor) signaling pathways and cellular responses.
• Metabolic Studies: Employed to study the stability and metabolic fate of prostaglandin analogs, aiding in the design of more durable drug candidates.
• Cell Culture & Physiology: Applied in controlled experiments to modulate processes such as smooth muscle contraction, vasodilation, and immune cell function.
• Chemical Synthesis: Serves as a sophisticated building block for the synthesis of more complex, proprietary prostaglandin derivatives and analogs.

Basic Information

Product Name	18,18,20-Trimethylprostaglandin E2
CAS No.	80003-51-6
Molecular Formula	C23H38O5
Molecular Weight	394.55 g/mol
Synonyms	Trimethyl PGE2; 11α,15α-Dihydroxy-9-oxo-18,18,20-trimethylprosta-5Z,13E-dien-1-oic Acid; 18,18,20-Trimethyl-PGE2; 18,18,20-Trimethylprostaglandin E2; 9-Oxo-11α,15α-dihydroxy-18,18,20-trimethylprosta-5Z,13E-dien-1-oic Acid; 18,18,20-Trimethyl Prostaglandin E2; PGE2 Trimethyl Analog
EINECS	Contact for details

Quality Control

Our 18,18,20-Trimethylprostaglandin E2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.