Description

2,6-Dichloro-5-Fluoronicotinic Acid is a high-purity fluorinated nicotinic acid derivative that serves as a critical advanced pharmaceutical intermediate. Its value lies in its role as a versatile building block for synthesizing complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutics. This compound is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for scale-up and production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing fluorinated pyridine scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom and chlorinated pyridine structure contribute to biological activity.
• Chemical Research & Development: Serves as a versatile building block in organic synthesis for creating novel fluorinated heterocyclic compounds in academic and industrial labs.
• API Manufacturing: Employed in the commercial-scale production of Active Pharmaceutical Ingredients (APIs) requiring a precisely functionalized nicotinic acid core.
• Material Science Precursor: Potential use in the synthesis of specialty polymers, ligands for catalysis, or advanced materials where its specific halogenation pattern is advantageous.

Basic Information

Product Name	2,6-Dichloro-5-Fluoronicotinic Acid
CAS No.	8271-06-5
Molecular Formula	C6H2Cl2FNO2
Molecular Weight	209.99 g/mol
Synonyms	5-Fluoro-2,6-dichloronicotinic acid; 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid; 3-Carboxy-2,6-dichloro-5-fluoropyridine; 8271-06-5; 5-Fluoro-2,6-dichloropyridine-3-carboxylic acid; 2,6-Dichloro-5-fluoro-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2,6-Dichloro-5-Fluoronicotinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.