Description

2,6-Bis(Trifluoromethyl)-4-Pyrimidinol is a versatile fluorinated pyrimidine derivative, a key building block prized for its unique electronic and steric properties imparted by the trifluoromethyl groups. This compound is essential for researchers and manufacturers developing advanced materials and active pharmaceutical ingredients (APIs) where enhanced stability, lipophilicity, and metabolic resistance are required. It is primarily utilized in the synthesis of agrochemicals, pharmaceuticals, and specialty chemicals for electronics and material science applications.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental persistence.
• Material Science: Serves as a precursor for organic electronic materials, including ligands for metal-organic frameworks (MOFs) and components for organic light-emitting diodes (OLEDs).
• Chemical Research & Development: Employed as a standard or reagent in organic synthesis for introducing the bis(trifluoromethyl)pyrimidine moiety into complex molecules.
• Ligand in Catalysis: Can be utilized to create specialized ligands for transition metal catalysts used in cross-coupling and other synthetic transformations.

Basic Information

Product Name	2,6-Bis(Trifluoromethyl)-4-Pyrimidinol
CAS No.	884-30-0
Molecular Formula	C6H2F6N2O
Molecular Weight	232.09 g/mol
Synonyms	4-Pyrimidinol, 2,6-bis(trifluoromethyl)-; 2,6-Bis(trifluoromethyl)pyrimidin-4-ol; 4-Hydroxy-2,6-bis(trifluoromethyl)pyrimidine; 2,6-Bis(trifluoromethyl)-4(1H)-pyrimidinone; 2,6-Di(trifluoromethyl)-4-pyrimidinol; 4-Hydroxy-2,6-di(trifluoromethyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2,6-Bis(Trifluoromethyl)-4-Pyrimidinol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.