Description

Vinblastine is a naturally occurring alkaloid derived from the Madagascar periwinkle plant, Catharanthus roseus. This potent compound is a critical active pharmaceutical ingredient (API) in the formulation of injectable chemotherapy drugs. It is primarily utilized in the pharmaceutical and biotechnology industries for the treatment of various cancers. The product is supplied as Vinblastine CAS NO 865-21-4, meeting the stringent purity requirements for pharmaceutical manufacturing.

Application

• Oncological Therapeutics: As a key component in combination chemotherapy regimens for Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, breast cancer, and Kaposi's sarcoma.
• Pharmaceutical API Manufacturing: Serves as the primary active ingredient in the commercial production of injectable vinblastine sulfate formulations.
• Clinical Research & Drug Development: Used in preclinical and clinical studies investigating new cancer treatment protocols and combination therapies.
• Biochemical Research: Employed as a microtubule-disrupting agent in cell biology studies to investigate mitosis, cell cycle arrest, and mechanisms of apoptosis.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and other chromatographic assays.

Basic Information

Item	Details
Product Name	Vinblastine
CAS No.	865-21-4
Molecular Formula	C46H58N4O9
Molecular Weight	810.97 g/mol
Synonyms	Vincaleukoblastine; VLB; Vinblastine sulfate (salt); Exal; Velban; Velbe; 3',4'-Didehydro-4'-deoxy-8'-norvincaleukoblastine; Catharanthine, dimer with vindoline; [3aR-[3aα,4β,5β,5aβ,9(3R*,5S*,7R*,9S*),10aα,11α,12α,12aα,12bα]]-4-(Acetyloxy)-6,7-didehydro-3a,4,5,5a,6,7,8,9,10,10a,11,12,12a,12b,13,14-hexadecahydro-5-hydroxy-8-methoxy-3a,11,12a-trimethyl-1H-indolizino[8,1-cd]carbazol-5-yl methylcarbamate ester with methyl (2β,12β)-2,12-dihydroxy-2',3',4',5',6',7',12',12'a-octahydro-10-methoxy-2'-methyl-5'-(1-methyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)[1,3']diindolyl[3',4':3,4]pyrrolo[2,1-a]isoquinolin-10'-carboxylate
EINECS	212-729-2

Quality Control

Our Vinblastine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical-grade specifications, typically conforming to or exceeding relevant pharmacopoeial standards (e.g., USP, EP). A detailed Certificate of Analysis (COA) documenting identity, purity, potency, and related substances is provided with every shipment to ensure full traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 0.1 %
Related Substances (HPLC)	Total impurities ≤ 2.0%; Individual unknown impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Microbial Limits	Meets requirements for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.