Description

2-Nitro-4-(Trifluoromethyl)Benzenesulfonyl Chloride is a versatile and high-value sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value proposition lies in its dual functionality, enabling the introduction of both the sulfonamide group and the electron-withdrawing nitro-trifluoromethylphenyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties. Its reactivity makes it a key intermediate for developing compounds with specific biological activities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides that leverage the stability and bioactivity of the trifluoromethyl and sulfonamide groups.
• Dyestuff and Pigment Manufacturing: Serves as an intermediate for producing specialized azo dyes and high-performance pigments.
• Polymer Chemistry: Employed as a monomer or cross-linking agent to create functional polymers with specific surface properties or reactivity.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and material science research, facilitating structure-activity relationship (SAR) studies.
• Liquid Crystal and Electronic Material Synthesis: Used in the development of advanced organic electronic materials and liquid crystal compounds.

Basic Information

Item	Details
Product Name	2-Nitro-4-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	837-95-6
Molecular Formula	C7H3ClF3NO4S
Molecular Weight	289.61 g/mol
Synonyms	4-(Trifluoromethyl)-2-nitrobenzenesulfonyl chloride; 2-Nitro-α,α,α-trifluoro-p-toluenesulfonyl chloride; 4-Trifluoromethyl-2-nitrobenzenesulfonyl chloride; 2-Nitro-4-trifluoromethylbenzenesulfonyl chloride; Benzenesulfonyl chloride, 2-nitro-4-(trifluoromethyl)-; α,α,α-Trifluoro-2-nitro-p-toluenesulfonyl chloride; NSC 403107
EINECS	Contact for details

Quality Control

Our 2-Nitro-4-(Trifluoromethyl)Benzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP environments for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.