Description

4-Chloro-2,5-Dimethylbenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, primarily valued as a key synthetic intermediate in advanced organic synthesis. Its structure makes it an essential building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is critical for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the sulfonamide functional group with high regioselectivity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of sulfonamide-based drugs, including diuretics, anticonvulsants, and protease inhibitors.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and plant growth regulators where the sulfonyl moiety is required for biological activity.
• Dyestuff and Pigment Production: Serves as an intermediate for creating sulfonated dyes and pigments with enhanced solubility and color fastness.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers, such as polysulfones and ion-exchange resins.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.
• Ligand and Catalyst Preparation: Utilized to synthesize specialized ligands and organocatalysts for asymmetric synthesis and metal complexation.

Basic Information

Product Name	4-Chloro-2,5-Dimethylbenzenesulfonyl Chloride
CAS No.	88-49-3
Molecular Formula	C8H8Cl2O2S
Molecular Weight	239.12 g/mol
Synonyms	2,5-Dimethyl-4-chlorobenzenesulfonyl chloride; 4-Chloro-2,5-dimethylbenzene-1-sulfonyl chloride; 1-Chloro-4-sulfonyl chloride-2,5-dimethylbenzene; Benzenesulfonyl chloride, 4-chloro-2,5-dimethyl-; 88-49-3; 4-Chloro-2,5-xylenesulfonyl chloride; p-Chloro-m-xylene-2-sulfonyl chloride
EINECS	201-836-7

Quality Control

Our 4-Chloro-2,5-Dimethylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.