Description

Tubulysin I is a highly potent cytotoxic peptide isolated from myxobacteria. This compound is a key member of the tubulysin family, which are known for their exceptional ability to disrupt microtubule dynamics, leading to potent antiproliferative effects. It is primarily utilized by pharmaceutical researchers and biotechnology companies engaged in the development of next-generation antibody-drug conjugates (ADCs) and targeted cancer therapeutics. Its unique mechanism of action makes it a valuable tool compound for studying cell division and for the preclinical evaluation of novel oncology drug candidates.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly potent warhead in the development of targeted cancer therapies.
• Chemical Biology Research: Used as a molecular probe to study microtubule assembly, dynamics, and the mechanisms of mitosis.
• Oncology Drug Discovery: A critical reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel chemotherapeutic agents.
• Cytotoxicity Assays: Employed as a positive control in in vitro assays to evaluate the efficacy of other anticancer compounds.
• Structure-Activity Relationship (SAR) Studies: Provides the core scaffold for medicinal chemistry efforts to synthesize and evaluate analogs with improved properties.

Basic Information

Product Name	Tubulysin I
CAS No.	799822-10-9
Molecular Formula	C₄₃H₆₅N₅O₁₀S
Molecular Weight	844.07 g/mol
Synonyms	Tubulysin I; Tubulysin A; (-)-Tubulysin I; Tubulysin I, TUB I; (2S,4R)-4-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-[(2S,5S,8S,11S)-5,8-diisopropyl-11-[(1S)-1-methylpropyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methyl]-4,7,10-trioxo-3,6,9,12-tetraazatetradecyl]pentanoic acid
EINECS	Contact for details

Quality Control

Our Tubulysin I is manufactured under strict quality systems to ensure the highest standards of purity and consistency required for pharmaceutical research. Each batch is subjected to comprehensive analytical testing, including HPLC for purity determination and MS/NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support compliance with cGMP guidelines for API manufacturing where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.