Description

Tubulysin G is a highly potent antimitotic natural product belonging to the tubulysin family of tetrapeptide cytotoxins, originally isolated from myxobacterial strains. It exerts exceptional microtubule-destabilizing activity—often exceeding that of vinblastine and paclitaxel—making it a critical tool compound in oncology research and targeted drug conjugate (TDC) development. Researchers in pharmaceutical R&D, academic cancer biology labs, and biotech companies developing antibody–drug conjugates (ADCs) rely on high-purity Tubulysin G CAS NO 799822-08-5 for structure–activity relationship studies, linker optimization, and preclinical efficacy evaluation.

Application

• Lead compound in the design and synthesis of next-generation antibody–drug conjugates (ADCs) for solid tumor and hematologic malignancy targets
• In vitro and in vivo mechanistic studies of microtubule dynamics and mitotic arrest in human cancer cell lines
• Benchmarking agent for evaluating novel tubulin-binding therapeutics and resistance mechanisms
• Reference standard for analytical method development (HPLC, LC-MS) and assay validation in regulated bioanalytical laboratories
• Chemical probe for studying intracellular trafficking, endosomal escape, and payload release kinetics in TDC platforms
• Starting material for semi-synthetic derivatization to improve solubility, stability, or conjugation efficiency

Basic Information

Product Name	Tubulysin G
CAS No.	799822-08-5
Molecular Formula	C53H79N11O14
Molecular Weight	1102.26 g/mol
Synonyms	Tubulysin G; Tub-G; N-Methyl-N-(2-methylpropanoyl)-L-isoleucyl-L-N-methylvalyl-L-threonyl-L-tubuvaline; NSC 754217; UNII-7JQ0Z2Y8VX; CHEMBL4301705; SCHEMBL18522372; Z1122931181; Tubulysin G (natural)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of Tubulysin G is verified for identity (HPLC retention time match, HRMS, IR), purity (≥98.5% by HPLC), and absence of critical impurities (e.g., related tubulysins A–F, degradation products). Testing follows validated methods aligned with ICH Q2(R2) guidelines, and manufacturing adheres to ISO 9001-certified quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at –20 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity; handle in a controlled environment with desiccated conditions during weighing and dispensing.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (HRMS)	[M+H]+ m/z 1103.5924 ± 0.005 (calcd for C53H80N11O14)
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents (GC)	MeOH ≤3000 ppm; Acetonitrile ≤410 ppm; DCM ≤600 ppm
Water Content (KF)	≤5.0%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.