Description

β-Secretase Inhibitor Iv is a potent and selective small molecule inhibitor of the β-site amyloid precursor protein cleaving enzyme 1 (BACE1). This compound is of significant value in neuroscience research for its role in modulating the production of amyloid-beta peptides, which are central to the pathology of Alzheimer's disease. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in neurodegenerative disease research and drug discovery programs.

Application

• Alzheimer's Disease Research: A critical tool for investigating the amyloidogenic pathway and validating BACE1 as a therapeutic target in preclinical studies.
• Drug Discovery & Development: Used as a reference standard or lead compound in the screening and optimization of novel BACE1 inhibitors.
• Biochemical Assays: Employed in in vitro enzymatic assays to study BACE1 kinetics, inhibition mechanisms, and structure-activity relationships (SAR).
• Cellular & Animal Models: Applied in cell-based systems and transgenic animal models to assess the pharmacological effects of BACE1 inhibition on amyloid-beta plaque formation and cognitive function.
• Mechanistic Neurobiology: Facilitates studies on the non-amyloidogenic processing of APP and the broader physiological functions of BACE1.

Basic Information

Product Name	β-Secretase Inhibitor Iv
CAS No.	797035-11-1
Molecular Formula	C23H26F2N4O5S
Molecular Weight	508.54 g/mol
Synonyms	BACE1 Inhibitor IV; (3S,5S)-5-{[(5-Chloro-2-fluorophenyl)sulfonyl]amino}-3-{[2-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]methyl}-1,3-oxazolidin-2-one; GSK-188909; AZD-3839; (S)-5-((5-Chloro-2-fluorophenyl)sulfonamido)-3-((2-fluoro-4-(1H-1,2,4-triazol-1-yl)benzyl)oxazolidin-2-one; BACE Inhibitor 4
EINECS	Contact for details

Quality Control

Our β-Secretase Inhibitor Iv is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.