Description

2-Trifluoromethyl-5,6,7,8-tetrahydro-[1,6]naphthyridine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a fused naphthyridine ring system substituted with a trifluoromethyl group, makes it a critical intermediate for developing novel bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients with enhanced properties.

Application

The unique structural motif of this compound lends itself to several high-value applications in chemical research and development:

• Pharmaceutical Intermediate: Serves as a key scaffold in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, kinase inhibitors, and anti-infective agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Precursor: Acts as a building block for advanced organic materials, such as ligands for catalysts or components in organic electronic devices.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis to explore new chemical space for therapeutic applications.
• Fluorine Chemistry: A valuable substrate for studying the introduction and behavior of fluorine atoms in complex heterocyclic systems.

Basic Information

Product Name	2-Trifluoromethyl-5,6,7,8-tetrahydro-[1,6]naphthyridine
CAS No.	794461-84-0
Molecular Formula	C9H9F3N2
Molecular Weight	202.18 g/mol
Synonyms	5,6,7,8-Tetrahydro-2-(trifluoromethyl)-1,6-naphthyridine; 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; 1,6-Naphthyridine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)-; 794461-84-0; 2-Trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridine
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-5,6,7,8-tetrahydro-[1,6]naphthyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.