Description

5-Fluoropyridine-2-Boronic Acid Pinacol Ester is a high-purity, versatile boronic ester building block essential for modern synthetic chemistry. This compound is a critical reagent in cross-coupling reactions, enabling the efficient construction of complex fluorinated heterocyclic scaffolds. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery, catalyst development, and the synthesis of novel functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated pyridine derivatives, which are prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate fluorinated heterocycles for enhanced efficacy and environmental stability.
• Material Science: Serves as a precursor for creating fluorinated organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Catalyst Ligand Synthesis: Utilized to prepare sophisticated, fluorinated ligand systems for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Fluoropyridine-2-Boronic Acid Pinacol Ester
CAS No.	791819-04-0
Molecular Formula	C11H15BFNO2
Molecular Weight	223.05 g/mol
Synonyms	2-(5-Fluoropyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Fluoropyridin-2-yl)boronic acid pinacol ester; 5-Fluoro-2-pyridineboronic acid pinacol ester; 5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(5-Fluoropyridyl)boronic acid pinacol ester; 5-Fluoro-2-pyridylboronic acid pinacol ester; 5-Fluoro-2-(pinacolatoboryl)pyridine
EINECS	Contact for details

Quality Control

Our 5-Fluoropyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable and support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.