Description

Simotaxel CAS NO 791635-59-1 is a high-purity pharmaceutical intermediate and reference standard of significant importance in oncology research and development. This compound serves as a critical building block in the synthesis of novel taxane-based chemotherapeutic agents, which are vital for treating various cancers. It is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development of next-generation anticancer therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced taxane derivatives and prodrugs for cancer treatment.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing and regulatory submissions.
• Research & Development: Enables medicinal chemistry research focused on improving the efficacy and reducing the side effects of taxane chemotherapy.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) in pilot plants and commercial production.
• Academic Research: Utilized in university and institutional labs for studying the structure-activity relationships (SAR) of taxane compounds.

Basic Information

Product Name	Simotaxel
CAS No.	791635-59-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Simotaxel; (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Diacetoxy-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate; Cabazitaxel Impurity; Cabazitaxel Related Compound; Jevtana Impurity; Taxane Derivative
EINECS	Contact for details

Quality Control

Our Simotaxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.