Description

1,3-Dimethyl-2,4-Dioxo-1,2,3,4-Tetrahydro-Quinazoline-6-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative of a quinazoline-dione scaffold, serving as a critical building block for advanced chemical synthesis. Its value lies in enabling the precise introduction of the sulfonamide functional group, which is pivotal for modulating the biological activity and physicochemical properties of target molecules. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning compound libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting enzymes where the sulfonamide group acts as a pharmacophore.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides by serving as a precursor for sulfonamide-containing active ingredients.
• Chemical Biology Probes: Facilitates the creation of activity-based probes and affinity labels for studying protein function and enzyme mechanisms.
• Material Science: Potential precursor for functionalized polymers or organic electronic materials requiring specific sulfonamide linkages.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	1,3-Dimethyl-2,4-Dioxo-1,2,3,4-Tetrahydro-Quinazoline-6-Sulfonyl Chloride
CAS No.	773877-44-4
Molecular Formula	C₁₀H₉ClN₂O₄S
Molecular Weight	288.71 g/mol
Synonyms	6-(Chlorosulfonyl)-1,3-dimethyl-2,4(1H,3H)-quinazolinedione; 1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride; Quinazoline-6-sulfonyl chloride, 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-; 1,3-Dimethylquinazoline-2,4(1H,3H)-dione-6-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1,3-Dimethyl-2,4-Dioxo-1,2,3,4-Tetrahydro-Quinazoline-6-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.