Description

Acotiamide Hydrochloride Trihydrate is a high-purity pharmaceutical intermediate and active ingredient. This compound is a selective acetylcholinesterase inhibitor, making it a critical component in the development and manufacturing of functional gastrointestinal disorder treatments. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and contract development and manufacturing organizations (CDMOs) for the production of novel therapeutics.

Application

• Active Pharmaceutical Ingredient (API) for the treatment of functional dyspepsia and gastroparesis.
• Pharmaceutical Intermediate in the synthesis of advanced gastrointestinal prokinetic agents.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Clinical Research Material for formulation studies and preclinical/clinical trial manufacturing.
• Biochemical Research as a tool compound for studying acetylcholinesterase activity and gastrointestinal motility pathways.

Basic Information

Product Name	Acotiamide Hydrochloride Trihydrate
CAS No.	773092-05-0
Molecular Formula	C21H26ClN3O4S • 3H2O
Molecular Weight	502.00 g/mol (Trihydrate)
Synonyms	YM443; YM-443; Acotiamide HCl Trihydrate; N-[2-[Diisopropylamino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]thiazole-4-carboxamide Hydrochloride Trihydrate; (4,5-Dimethoxysalicyloyl)(2-(diisopropylamino)ethyl)aminothiazole-4-carboxamide Hydrochloride Trihydrate; Z-338 (Hydrochloride Trihydrate); FD-1001 (Hydrochloride Trihydrate)
EINECS	Contact for details

Quality Control

Our Acotiamide Hydrochloride Trihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5% (on anhydrous basis)
Water Content (KF)	9.0% - 11.0% (Theoretical for Trihydrate: ~10.8%)
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.