Description

R-(+)-Warfarin-D5 CAS NO 773005-79-1 is a high-purity, isotopically labeled internal standard of the anticoagulant drug warfarin, specifically the R-(+) enantiomer. This compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) engaged in drug development and therapeutic drug monitoring.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS assays for the precise quantification of warfarin in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical research.
• Metabolite Identification & Profiling: Used in mass spectrometry to differentiate drug-derived metabolites from endogenous compounds, facilitating metabolic pathway elucidation.
• Therapeutic Drug Monitoring (TDM): Critical for developing and validating robust clinical assays to monitor warfarin levels in patients, aiding in personalized anticoagulation therapy.
• Method Development & Validation: A key component for establishing FDA/EMA-compliant analytical methods, ensuring specificity, accuracy, and precision.
• Forensic & Doping Control Analysis: Employed in confirmatory testing for the presence of warfarin in forensic toxicology and anti-doping programs.

Basic Information

Product Name	R-(+)-Warfarin-D5
CAS No.	773005-79-1
Molecular Formula	C19H11D5ClO4
Molecular Weight	312.75 g/mol (for D5 isotopologue)
Synonyms	(R)-(+)-Warfarin-d5; (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one-d5; R-Warfarin-d5; (R)-Warfarin-d5; Warfarin (R-enantiomer)-d5; 3-(α-Acetonylbenzyl)-4-hydroxycoumarin-d5 (R-form); Coumadin-d5 (R-enantiomer); Isotopically labeled R-Warfarin
EINECS	Contact for details

Quality Control

Our R-(+)-Warfarin-D5 is manufactured under strict quality control protocols to ensure the highest standards of chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and residual solvents. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.