Description

((2S,3R)-3-(4-Bromophenyl)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Phenyl-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone is a sophisticated chiral organofluorine building block of significant interest in advanced synthetic chemistry. Its complex structure, featuring a stereodefined dihydrofuran core, a bromophenyl group, and a perfluorinated sulfonyl moiety, makes it a high-value intermediate for constructing molecules with specific three-dimensional architectures. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors who require specialized fluorinated synthons to modulate the biological activity, metabolic stability, and physicochemical properties of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the synthesis of advanced pesticide and herbicide candidates, where the fluorinated sulfonyl group can enhance lipophilicity, membrane permeability, and environmental stability.
• Material Science Exploration: Acts as a monomer or functional additive in the development of specialty polymers, liquid crystals, or organic electronic materials requiring fluorinated components for specific dielectric or surface properties.
• Asymmetric Catalysis Ligand Precursor: The chiral dihydrofuran scaffold can be utilized to develop novel ligands for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Medicinal Chemistry Probe: Employed in structure-activity relationship (SAR) studies to investigate the role of fluorination and stereochemistry on binding affinity and pharmacokinetic profiles.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical manufacturers and CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects for client-specific molecules.

Basic Information

Product Name	((2S,3R)-3-(4-Bromophenyl)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Phenyl-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone
CAS No.	771491-22-6
Molecular Formula	C27H16BrClF8O4S
Molecular Weight	719.82 g/mol
Synonyms	(2S,3R)-3-(4-Bromophenyl)-4-(4-chloro-1,1,2,2,3,3,4,4-octafluorobutylsulfonyl)-5-phenyl-2,3-dihydrofuran-2-yl(phenyl)methanone; Phenyl[(2S,3R)-3-(4-bromophenyl)-4-[(4-chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-5-phenyl-2,3-dihydro-2-furanyl]methanone; 771491-22-6; Chiral Fluorinated Dihydrofuranone Sulfone; 4-Bromo-α-phenyl-β-[(4-chlorooctafluorobutyl)sulfonyl]benzenepropanolide (stereospecific); SCHEMBL23545427; AKOS040759623; FT-0770727
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and chiral integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports our customers' needs for reliable and consistent material in their critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.