Description

Trifluoroacetic Acid CAS NO 76-05-1 is a highly versatile and potent fluorinated organic acid. Its strong acidity and excellent solvating properties make it a critical reagent and solvent in advanced chemical synthesis and purification processes. This compound is essential for industries requiring high-performance chemical intermediates, including pharmaceuticals, agrochemicals, and specialty polymers.

Application

• Pharmaceutical Synthesis: As a key reagent for peptide synthesis (as a cleavage and deprotection agent) and as a solvent for HPLC.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, pesticides, and fluorinated active ingredients.
• Polymer & Resin Production: Serves as a catalyst and solvent in the production of specialty polymers, including fluoropolymers and liquid crystal polymers (LCPs).
• Organic Synthesis & Catalysis: A powerful solvent and acid catalyst for various reactions, including esterifications, oxidations, and rearrangements.
• Analytical Chemistry: Employed as a mobile phase modifier in liquid chromatography-mass spectrometry (LC-MS) for improved separation and ionization.
• Chemical Derivatization: Used to prepare volatile derivatives of complex molecules for gas chromatographic analysis.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	76-05-1
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; Acetic Acid, Trifluoro-; 2,2,2-Trifluoroacetic Acid; CF3COOH; Kyselina trifluoroctova; Trifluoressigsaeure
EINECS	200-929-3

Quality Control

Our Trifluoroacetic Acid is manufactured under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assay, impurity profiling, and physical property verification, to ensure it meets the high-purity standards required for pharmaceutical and industrial applications. Certificates of Analysis (COA) are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines, internal specifications).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and strong acid/organic solvent nature, containers must be kept tightly sealed to prevent moisture absorption and release of vapors. Recommended storage temperature: 15-25°C.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Residue on Evaporation	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm
Heavy Metals (as Pb)	≤ 5 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.