Description

4-Fluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 4-fluorobenzoyl moiety, a key structural feature in numerous high-value compounds. This intermediate is essential for manufacturers and R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in manufacturing herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated compounds used in electronic displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering material properties like chemical resistance and thermal stability.
• Dyestuff and Pigment Manufacturing: Intermediate for creating specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Cross-coupling Reactions: Acts as an electrophile in palladium-catalyzed and other cross-coupling reactions to form complex biaryl structures.

Basic Information

Product Name	4-Fluorobenzoyl Chloride
CAS No.	403-43-0
Molecular Formula	C7H4ClFO
Molecular Weight	158.56 g/mol
Synonyms	p-Fluorobenzoyl Chloride; 4-Fluorobenzoic Acid Chloride; 4-Fluorobenzenecarbonyl Chloride; p-Fluorobenzoic Acid Chloride; 4-Fluorobenzoyl Chloride; Benzoic acid, 4-fluoro-, chloride; UN 3265; Corrosive liquid, acidic, organic, n.o.s.
EINECS	206-965-5

Quality Control

Our 4-Fluorobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, GC for residual solvents, and IR/NMR for structural confirmation, to ensure it meets precise customer specifications. Certificates of Analysis (COA) detailing all test results are provided with each shipment. We adhere to cGMP principles where applicable and can support regulatory filings for pharmaceutical customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, alcohols, and amines. Recommended storage temperature is 2-8°C for long-term stability. The container must be kept tightly sealed due to moisture sensitivity and reactivity with atmospheric humidity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 1.5%
Density (at 20°C)	~1.33 g/cm³
Boiling Point	~185-187°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.