Description

Heptafluorobutyrylamidine CAS NO 375-19-9 is a specialized fluorinated amidine derivative, a key building block in advanced organic synthesis. Its unique structure, featuring a highly fluorinated butyryl group, makes it a valuable reagent for introducing fluorinated moieties into target molecules, which is critical for modifying physical and chemical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to create advanced fluorinated herbicides, fungicides, and insecticides, where the fluorine atoms improve efficacy and environmental profile.
• Material Science: Serves as a monomer or modifier in the production of specialty polymers and coatings with enhanced chemical resistance, thermal stability, and low surface energy.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and dielectric materials.
• Organic Synthesis Reagent: Acts as a versatile fluorinating agent and building block in complex organic transformations, including cyclization and cross-coupling reactions.
• Research & Development: A valuable tool for medicinal chemistry and chemical biology research focused on structure-activity relationship (SAR) studies involving fluorine.

Basic Information

Product Name	Heptafluorobutyrylamidine
CAS No.	375-19-9
Molecular Formula	C4H2F7N
Molecular Weight	197.06 g/mol
Synonyms	Perfluorobutyrylamidine; 2,2,3,3,4,4,4-Heptafluorobutanimidamide; Heptafluorobutyrimidamide; Nonafluorobutanimidamide (incorrect but common); CF3(CF2)2C(=NH)NH2; Pentafluoroethyl trifluoroacetamidine; Heptafluorobutyryl amidine
EINECS	206-795-5

Quality Control

Our Heptafluorobutyrylamidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.