Description

Dimethyl Difluoromalonate is a specialized fluorinated building block essential for introducing the difluoromethylene group into complex molecular architectures. This compound matters for its unique reactivity, enabling the synthesis of high-value fluorinated intermediates with applications in advanced materials and life sciences. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to enhance the metabolic stability and bioavailability of their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated analogs of bioactive molecules, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where fluorine substitution improves environmental persistence and activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of fluorinated polymers with enhanced chemical and thermal resistance.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and condensation reactions to incorporate the -CF2- moiety into complex organic frameworks.
• Liquid Crystal & Electronic Chemical Production: Used in the synthesis of fluorinated liquid crystals and dielectric materials for display and semiconductor applications.

Basic Information

Product Name	Dimethyl Difluoromalonate
CAS No.	379-95-3
Molecular Formula	C5H6F2O4
Molecular Weight	168.10 g/mol
Synonyms	Dimethyl 2,2-Difluoromalonate; Difluoromalonic Acid Dimethyl Ester; Methyl Difluoromalonate; 2,2-Difluoromalonic Acid Dimethyl Ester; Dimethyl 2,2-Difluoropropanedioate; Propanedioic Acid, 2,2-Difluoro-, Dimethyl Ester; DFMM
EINECS	206-815-7

Quality Control

Our Dimethyl Difluoromalonate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly closed and stored under an inert atmosphere if prolonged storage is anticipated.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.