Description

4-Chloro-4'-Fluorobutyrophenone is a high-purity organic building block of significant importance in advanced chemical synthesis. Its unique structure, featuring both chloro and fluoro substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those with neurological or anti-inflammatory properties.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluorinated aromatic system.
• Liquid Crystal & OLED Material Research: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and optoelectronic devices.
• Chemical Research & Development: Employed as a standard reagent in organic chemistry labs for studying Friedel-Crafts acylation and subsequent functional group transformations.
• Custom Synthesis Building Block: Provides a critical scaffold for contract research organizations (CROs) and CDMOs developing proprietary compounds for clients.

Basic Information

Product Name	4-Chloro-4'-Fluorobutyrophenone
CAS No.	3874-54-2
Molecular Formula	C10H10ClFO
Molecular Weight	200.64 g/mol
Synonyms	1-(4-Chlorophenyl)-4-fluoro-1-butanone; 4'-Fluoro-4-chlorobutyrophenone; p-Chloro-p'-fluorobutyrophenone; Butyrophenone, 4-chloro-4'-fluoro-; 4-Chloro-4-fluorobutyrophenone; 4-Fluoro-4'-chlorobutyrophenone; 3874-54-2; NSC 406079
EINECS	223-393-6

Quality Control

Every batch of 4-Chloro-4'-Fluorobutyrophenone is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.