Description

Bay 65-1942 (R Form) is a high-purity, enantiomerically pure small molecule compound, specifically the R-enantiomer of the selective IKK-β inhibitor. This compound is a critical research-grade chemical used extensively in biochemical and pharmacological studies to investigate inflammatory signaling pathways, particularly those involving the NF-κB complex. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors who require precise, high-quality chemical tools for target validation, mechanism-of-action studies, and preclinical drug discovery programs.

Application

• Biochemical Research: A key tool for studying the specific role of IKK-β kinase activity in cellular signaling cascades.
• Pharmaceutical R&D: Used in high-throughput screening (HTS) and target validation assays for anti-inflammatory and oncology drug discovery.
• Mechanistic Studies: Enables detailed investigation of NF-κB pathway inhibition and its downstream effects in various disease models.
• Academic Research: Supports fundamental research in immunology, cell biology, and molecular pharmacology at universities and research institutes.
• Preclinical Development: Serves as a reference standard or active pharmaceutical ingredient (API) intermediate in early-stage therapeutic development.

Basic Information

Product Name	Bay 65-1942 (R Form)
CAS No.	758683-21-5
Molecular Formula	C₂₀H₂₀N₄O₂S
Molecular Weight	380.46 g/mol
Synonyms	(R)-N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxy-4-(1-methyl-1H-indazol-5-yl)benzamide; (R)-Bay 65-1942; (R)-N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-4-(1-methyl-1H-indazol-5-yl)-2-hydroxybenzamide; IKK-2 Inhibitor V, (R)-Isomer; (R)-5-Chloro-2-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-4-(1-methyl-1H-indazol-5-yl)benzamide; Bay-65-1942 R-Form
EINECS	Contact for details

Quality Control

Our Bay 65-1942 (R Form) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC to confirm enantiomeric excess. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.