Description

1-Chloro-4-Ethynyl-2-Fluoro-Benzene is a high-purity, multi-functional aromatic building block featuring a unique combination of halogen and alkyne functional groups. This compound is critical for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymers and functional organic materials.
• Ligand and Catalyst Development: The ethynyl group provides a handle for constructing sophisticated ligands for catalysis and molecular recognition.
• Chemical Biology Probes: Employed in click chemistry (CuAAC) applications to create labeled probes for studying biological systems.
• Academic & Industrial R&D: A versatile scaffold for methodological development in organic chemistry and discovery chemistry programs.

Basic Information

Product Name	1-Chloro-4-Ethynyl-2-Fluoro-Benzene
CAS No.	756895-72-4
Molecular Formula	C8H4ClF
Molecular Weight	154.57 g/mol
Synonyms	2-Fluoro-4-chlorophenylacetylene; 4-Chloro-2-fluorophenylacetylene; 1-Chloro-4-ethynyl-2-fluorobenzene; 2-Fluoro-4-chloro-1-ethynylbenzene; (4-Chloro-2-fluorophenyl)ethyne; 4-Chloro-2-fluoroethynylbenzene; 756895-72-4
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Ethynyl-2-Fluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, impurity profiles, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.