Description

2-Bromo-4-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate essential for advanced organic synthesis. Its unique structure, featuring both a sulfonyl chloride and a bromo-trifluoromethoxy aryl group, makes it a critical building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs and molecules requiring trifluoromethoxy or bromoaryl motifs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the sulfonyl chloride group enables the introduction of sulfonamide linkages.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of chemical probes, activity-based protein profiling (ABPP) reagents, and covalent inhibitors.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	2-Bromo-4-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride
CAS No.	752132-49-3
Molecular Formula	C7H3BrClF3O3S
Molecular Weight	339.51 g/mol
Synonyms	1-Bromo-2-(Trifluoromethoxy)-4-(Chlorosulfonyl)Benzene; 2-Bromo-4-(Trifluoromethoxy)Benzenesulfonyl Chloride; 4-Bromo-2-(Trifluoromethoxy)Benzenesulfonyl Chloride; 2-Bromo-α,α,α-trifluoro-p-anisolesulfonyl chloride; Benzenesulfonyl chloride, 2-bromo-4-(trifluoromethoxy)-; 752132-49-3
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and GC-MS to verify identity, purity, and impurity profiles. Our quality commitment ensures material consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.