Description

4-Bromo-1-Difluoromethyl-2-Fluorobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a difluoromethyl group, makes it a versatile intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting new fluorinated small molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl and fluorine groups can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, where halogenated aromatics modify electronic and physical properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of multiple fluorine atoms on molecular conformation, lipophilicity, and reactivity in academic and industrial R&D settings.

Basic Information

Item	Detail
Product Name	4-Bromo-1-Difluoromethyl-2-Fluorobenzene
CAS No.	749932-17-0
Molecular Formula	C7H4BrF3
Molecular Weight	224.99 g/mol
Synonyms	2-Fluoro-4-bromo-α,α-difluorotoluene; 4-Bromo-2-fluoro-α,α-difluorotoluene; 1-Bromo-4-(difluoromethyl)-3-fluorobenzene; 4-Bromo-2-fluorobenzylidene difluoride; (4-Bromo-2-fluorophenyl)difluoromethane
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Difluoromethyl-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.