Description

1-[3-(Trifluoromethyl)Pyridin-2-Yl]Ethan-1-One is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring a trifluoromethyl group and a ketone functional group, makes it an essential intermediate for creating compounds with enhanced metabolic stability and lipophilicity. This product is primarily needed by pharmaceutical R&D teams and agrochemical manufacturers developing new active ingredients, as well as by specialty chemical companies focused on material science and electronics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic and optical applications.
• Chemical Biology Probes: Utilized as a building block for fluorinated probes and tags used in bioimaging and proteomics studies.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Pyridin-2-Yl]Ethan-1-One
CAS No.	749257-78-1
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	2-Acetyl-3-(trifluoromethyl)pyridine; 1-[3-(Trifluoromethyl)-2-pyridinyl]ethanone; 3-(Trifluoromethyl)-2-acetylpyridine; 2-Pyridineethanone, 3-(trifluoromethyl)-; Ethanone, 1-[3-(trifluoromethyl)-2-pyridinyl]-; 2-Acetyl-α,α,α-trifluoro-3-picoline
EINECS	Contact for details

Quality Control

Our 1-[3-(Trifluoromethyl)Pyridin-2-Yl]Ethan-1-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.