Description

Ck2 Inhibitor Ii CAS NO 749234-11-5 is a potent and selective small molecule inhibitor of casein kinase 2 (CK2), a serine/threonine kinase implicated in numerous cellular processes. This compound is a critical research tool for investigating CK2's role in cell signaling, proliferation, and survival pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurology, and molecular biology research.

Application

• Biochemical Research: Used as a selective probe to study CK2 kinase activity, substrate specificity, and downstream signaling cascades in vitro.
• Cell-Based Assays: Applied in cellular models to investigate the functional role of CK2 in processes such as cell cycle regulation, apoptosis, and DNA damage response.
• Drug Discovery & Target Validation: Serves as a key pharmacological tool in preclinical research for validating CK2 as a therapeutic target in various disease models, particularly cancer.
• Academic & Institutional Research: Supports fundamental research in universities and institutes exploring kinase biology and signal transduction mechanisms.
• High-Throughput Screening (HTS): Can be used as a reference compound in HTS campaigns to identify novel CK2 inhibitors or to assess assay performance.

Basic Information

Product Name	Ck2 Inhibitor Ii
CAS No.	749234-11-5
Molecular Formula	C19H17N5O2
Molecular Weight	347.37 g/mol
Synonyms	CK2 Inhibitor II; 4,5,6,7-Tetrabromobenzotriazole (TBBt) derivative; 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole; TBBz; Casein Kinase II Inhibitor II; 4,5,6,7-Tetrabromo-2-(dimethylamino)benzimidazole; CK2 Inhibitor, TBBz; 749234-11-5
EINECS	Contact for details

Quality Control

Our Ck2 Inhibitor Ii is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure high batch-to-batch consistency and reliability for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.