Description

Desmethyl Tiagabine Hydrochloride is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for analytical research, method development, and quality control processes in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, pharmaceutical manufacturers, and quality control laboratories involved in neuropharmacology and anticonvulsant drug development.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of Tiagabine and related compounds via HPLC, LC-MS, and other chromatographic methods.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the research and production of Tiagabine hydrochloride and its derivatives.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to study the biotransformation of Tiagabine.
• Analytical Method Development: Essential for developing and validating impurity profiling and stability-indicating assay methods for pharmaceutical quality control.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., with FDA, EMA) by providing a characterized impurity standard for drug substance specifications.

Basic Information

Product Name	Desmethyl Tiagabine Hydrochloride
CAS No.	748741-38-0
Molecular Formula	C19H25ClNO2S2
Molecular Weight	406.00 g/mol
Synonyms	(R)-(-)-N-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic Acid Hydrochloride; (3R)-1-[4,4-Bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic Acid Hydrochloride; Desmethyl Tiagabine HCl; Tiagabine Desmethyl Impurity; Tiagabine Related Compound; Tiagabine Metabolite Standard; (R)-N-[4,4-Di(3-methyl-2-thienyl)-3-butenyl]nipecotic Acid Hydrochloride
EINECS	Contact for details

Quality Control

Our Desmethyl Tiagabine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profile determination by HPLC, to ensure it meets stringent specifications for pharmaceutical reference standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, purity, and consistency for your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.