Description

3-Chloro-2-Fluoroisonicotinic Acid is a high-purity, multi-functional heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in its unique halogenated pyridine structure, which serves as a critical precursor for constructing complex molecules with tailored biological and physical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Serves as a foundational building block for developing new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Employed in the creation of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trials.

Basic Information

Product Name	3-Chloro-2-Fluoroisonicotinic Acid
CAS No.	741683-19-2
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.55 g/mol
Synonyms	3-Chloro-2-fluoropyridine-4-carboxylic acid; 2-Fluoro-3-chloroisonicotinic acid; 4-Pyridinecarboxylic acid, 3-chloro-2-fluoro-; 3-Chloro-2-fluoro-4-pyridinecarboxylic acid; 2-Fluoro-3-chloro-4-carboxypyridine; 3-Chloro-2-fluoropyridine-4-carboxylic acid; 741683-19-2 (CAS)
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoroisonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production facilities and quality protocols are designed to support development and commercial needs, including those requiring ICH stability guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.