Description

Gsk-3 Inhibitor X CAS NO 740841-15-0 is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase with critical roles in cellular signaling pathways. This compound is essential for researchers and developers in the life sciences sector, providing a key tool for modulating Wnt/β-catenin signaling and investigating mechanisms related to neurological disorders, diabetes, and cancer. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Drug Discovery & Pharmaceutical Research: A critical tool for high-throughput screening and target validation in programs focused on Alzheimer's disease, bipolar disorder, and type 2 diabetes.
• Academic & Biomedical Research: Used to study the fundamental roles of GSK-3 in cell proliferation, differentiation, apoptosis, and insulin signaling pathways.
• Oncology Research: Investigated for its potential to inhibit tumor growth and sensitize cancer cells to chemotherapy by modulating β-catenin activity.
• Neurological Disease Modeling: Applied in vitro and in vivo to create models and explore therapeutic interventions for tauopathies and mood disorders.
• Stem Cell Research: Facilitates the maintenance and differentiation of stem cells by regulating the Wnt signaling pathway.
• Biochemical Assay Development: Serves as a reference standard and positive control in kinase inhibition assays and other enzymatic studies.

Basic Information

Product Name	Gsk-3 Inhibitor X
CAS No.	740841-15-0
Molecular Formula	C₁₆H₁₂N₈O
Molecular Weight	332.32 g/mol
Synonyms	6-[[2-[[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; CHIR 99021; CT99021; CHIR99021; GSK-3 Inhibitor XV; Axitinib analog; GSK-3β inhibitor CHIR99021; CAS 252917-06-9 (related salt form)
EINECS	Contact for details

Quality Control

Our Gsk-3 Inhibitor X is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure identity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing all critical quality attributes. Our production adheres to standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.