Description

Pkc-Theta Inhibitor CAS NO 736048-65-0 is a potent and selective small molecule inhibitor of the protein kinase C theta (PKCθ) isoform. This compound is a critical research tool for investigating T-cell activation, proliferation, and immune signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in immunology, oncology, and autoimmune disease research.

Application

• Immunological Research: Used to study the role of PKCθ in T-cell receptor (TCR) signaling, T-cell anergy, and immune synapse formation.
• Autoimmune Disease Studies: Investigated as a potential therapeutic target for conditions like rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease.
• Oncology Research: Applied in research exploring T-cell function in the tumor microenvironment and the development of immunotherapies.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) and kinase selectivity profiling assays.
• Mechanism of Action Studies: Employed to elucidate downstream signaling pathways involving NF-κB and AP-1 transcription factors.
• Preclinical Drug Discovery: Used in in vitro and in vivo models to validate PKCθ as a target and assess the efficacy of novel inhibitor candidates.

Basic Information

Product Name	Pkc-Theta Inhibitor
CAS No.	736048-65-0
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	PKCθ Inhibitor; 8-(4-Fluorophenyl)-2-({4-[(methylsulfonyl)amino]phenyl}amino)-1,7-naphthyridine-3-carbonitrile; 8-(4-Fluorophenyl)-2-({4-[(methylsulfonyl)amino]phenyl}amino)-1,7-naphthyridine-3-carbonitrile; PKC Theta Inhibitor; Protein Kinase C Theta Inhibitor; CAS 736048-65-0
EINECS	Contact for details

Quality Control

Our Pkc-Theta Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.