Description

Nsc 23766 Tetrahydrochloride is a high-purity, small molecule inhibitor primarily used in biochemical and pharmacological research. This compound is valued for its specific activity as a Rac1 GTPase inhibitor, making it a critical tool for studying cellular signaling pathways related to cell proliferation, morphology, and metastasis. It is essential for research laboratories and pharmaceutical development teams focused on oncology, neurology, and cardiovascular disease mechanisms. Consistent quality and reliable supply are paramount for ensuring reproducible experimental results in these fields.

Application

• Biochemical Research: Used as a selective inhibitor of Rac1 GTPase to study its role in actin cytoskeleton dynamics and cell motility.
• Oncology Research: Investigated for its potential to inhibit cancer cell invasion, metastasis, and tumor angiogenesis in preclinical models.
• Neuroscience Studies: Applied in research exploring Rac1 signaling pathways in neuronal development, synaptic plasticity, and neurodegenerative diseases.
• Cardiovascular Research: Utilized to examine the role of Rac1 in vascular smooth muscle cell function, hypertension, and cardiac hypertrophy.
• Pharmaceutical Development: Serves as a reference standard or lead compound in drug discovery programs targeting GTPase-mediated pathways.
• Cell Biology Assays: A key reagent in high-throughput screening (HTS) and functional assays to identify modulators of Rho family GTPases.

Basic Information

Product Name	Nsc 23766 Tetrahydrochloride
CAS No.	733767-34-5
Molecular Formula	C₂₀H₃₂Cl₄N₆O₂
Molecular Weight	530.32 g/mol
Synonyms	NSC 23766; NSC-23766; NSC23766; Rac1 Inhibitor; 6-[2-[4-(Diethylamino)butyl]-5,6,7,8-tetrahydro-4(1H)-quinazolinylidene]-3(2H)-pyridazinone tetrahydrochloride; 1,4-Diazepine-6-carboxamide, N-(1,1-dimethylethyl)-1,2,3,5-tetrahydro-7-nitro-2-oxo-, hydrochloride (1:?); (Rac)-N-[(1,1-Dimethylethoxy)carbonyl]-1,2,3,5-tetrahydro-7-nitro-2-oxo-1,4-benzodiazepine-6-carboxamide hydrochloride
EINECS	Contact for details

Quality Control

Our Nsc 23766 Tetrahydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets high-grade research standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.