Description

Bay 61-3606 CAS NO 732983-37-8 is a potent and selective small molecule inhibitor of the spleen tyrosine kinase (Syk). This compound is a critical research tool for investigating intracellular signaling pathways, particularly those involved in immunoreceptor and integrin signaling. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and immunological studies.

Application

• Biochemical Research: A key reagent for studying Syk-dependent signal transduction in immune cells like B-cells, mast cells, and macrophages.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in preclinical research for autoimmune, inflammatory, and allergic diseases.
• Cellular Pathway Analysis: Employed in vitro to elucidate the role of Syk in cell adhesion, proliferation, and phagocytosis.
• Target Validation: Serves as a selective inhibitor to confirm Syk as a therapeutic target in various experimental models.

Basic Information

Product Name	Bay 61-3606
CAS No.	732983-37-8
Molecular Formula	C₂₀H₂₂N₆O₂
Molecular Weight	378.43 g/mol
Synonyms	Bay 61-3606; 2-[(7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino]pyridine-3-carboxamide; 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide; Syk Inhibitor; Syk Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Bay 61-3606 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.