Description

Got1 Inhibitor 2C is a potent and selective small molecule inhibitor targeting the GOT1 enzyme, a key component in cellular metabolism and redox balance. This compound is crucial for researchers investigating novel therapeutic strategies in oncology and metabolic disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer metabolism and drug discovery.

Application

• Biomedical Research: Used as a critical tool compound for studying glutamine metabolism, the malate-aspartate shuttle, and cellular redox homeostasis in cancer cell lines.
• Drug Discovery & Development: Serves as a lead compound or pharmacologic probe in preclinical studies for targeting cancers dependent on altered glutaminolysis, such as pancreatic ductal adenocarcinoma.
• Mechanistic Studies: Enables the investigation of GOT1's role in tumor progression, metastasis, and resistance to conventional therapies.
• Target Validation: Supports functional genomics and target validation efforts in metabolic pathway research.
• High-Throughput Screening (HTS): Can be used as a reference standard in assay development and screening campaigns for identifying novel GOT1 modulators.
• In vitro & In vivo Models: Applied in both cell-based assays and animal models to evaluate the therapeutic potential of inhibiting GOT1.

Basic Information

Product Name	Got1 Inhibitor 2C
CAS No.	732973-87-4
Molecular Formula	C21H21N5O3S
Molecular Weight	423.49 g/mol
Synonyms	GOT1-IN-2; GOT1 Inhibitor; 2-[[5-[(2,4-Difluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-fluorophenyl)acetamide]; (2Z)-2-[[5-[(2,4-Difluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-fluorophenyl)acetamide]; Aspartate Aminotransferase 1 Inhibitor; GOT1-IN-2C; Inhibitor of Glutamic-Oxaloacetic Transaminase 1
EINECS	Contact for details

Quality Control

Our Got1 Inhibitor 2C is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.